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The best time of day for administering medications

Posted by Constance Schein, RN
on June 19, 2019
an elderly hand holding white pills.

Part of the role of a caregiver is making sure that seniors are getting the medications that they need to stay healthy. It’s not uncommon for dementia patients to take a variety of prescriptions for their conditions. These may be in addition to common drugs used for other illnesses, such as osteoporosis or high blood pressure.

Despite the importance of taking medication correctly, the only advice you will likely get from a label is to take pills once a day. However, according to Harvard Health Publishing, the time of day medications are taken can have a major effect on health and well-being.

“The body doesn’t respond to medications in the same way at different times of the day,” Dr. Michael Smolensky, an adjunct professor of biomedical engineering at the University of Texas, Austin, explained to AARP.  “Some drugs are not as effective or as well tolerated if they’re taken at the wrong biological time. It’s not that they’re not effective at all, but they’re certainly much less effective.”

How our biological clocks affect medications

Each of us has an internal clock that is connected to the cycle of the rising and setting sun. Several organs, tissues and cells within the body function in a direct response to different 24-hour periods. The time of day your parent takes medications may be vital for maximizing their true effectiveness. And it can also help her avoid potentially dangerous drug reactions. Everything from body temperature, hormone secretion, immune system function, digestion and levels of fatigue are greatly influenced by the time of day.

It’s also important to note that the specific type of drug your parent is taking can also become more potent based on our biological clocks. This is why it is very important that you meet with your doctor to discuss what medications your mom is taking, including herbal supplements and vitamins or if she is following a restricted diet for another condition, such as low-sodium or low-sugar, according to the Cleveland Clinic.

Certain medications require a specific time of day

There are a variety of medications your parent may be taking to manage different health issues as he or she ages. But have you given any thought to what time of day your loved one takes his or her prescriptions? Depending on the condition and medication an individual is taking, medication time is important.


Some of the most common drugs for osteoporosis include bisphosphonates, which work to reduce the risk of bone loss. The only problem is that these drugs do not dissolve or absorb into the bloodstream as well as other drugs, especially when mixed with oils and fats. This is why medical professionals advise taking bisphosphonates on an empty stomach with water in the morning before breakfast. The best medication time is at least an hour before eating so that the medication can be fully absorbed.

High blood pressure:

According to the Centers for Disease Control and Prevention, around 1 in 3 adults in the U.S. struggles with high blood pressure. This means that it’s likely your loved one will be prescribed a medication for the condition – especially since the chances for heart disease and stroke increase as we age. For hypertension, taking a medication at night is highly advised, according to several leading experts. A five-year Spanish study conducted at the University of Vigo allowed researchers to look at more than 2,100 men and women with high blood pressure, and those who took their medications at night had a 33 percent lower risk of angina, stroke and heart attack when compared to those who took their drugs when they woke up. If you are thinking about changing your loved one’s hypertension medication regimen, be sure to speak with your doctor first to see if there are any outlying cardiovascular risks.

High cholesterol:

In the past decade, doctors have largely switched their recommendation for taking medications for high cholesterol in the morning to right before bed. This is because these medications are linked with fewer heart attacks, higher levels of “good” cholesterol and improved arterial blood flow. As Dr. B. Greg Brown pointed out to ABC News, the liver works its hardest at night, so taking medications before bed lowers cholesterol levels as the blood circulates through the body.

Keeping your parent safe and healthy with his or her prescriptions is one of the most crucial aspects of your role as a caregiver. Although there are several medications that might be more appropriate to take during certain times of day, we recommend that you check with your parent’s doctor and pharmacist before making changes to his or her treatment plans. They should be happy to assist you in providing the most effective and safe care possible, offering the best medication time for each prescription.

Aegis Living’s care professionals can also discuss the best medication times for your mom depending on her health history, types of medications and diet.

Profile image of Constance Schein, RN

Constance Schein, RN

Former Senior Vice President of Clinical and Health Services

Constance Schein is a registered nurse with more than 25 years of nursing experience in senior-focused healthcare organizations. She led Aegis Living’s major nursing and care initiatives and was responsible for managing and developing healthcare partnerships, technology, and wellness programs to improve resident care.

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